AB1424 CLINICAL VARIABILITY IN PATIENTS DIAGNOSED OF JUVENILE IDIOPATHIC ARTHRITIS WITH POSITIVE AND NEGATIVE ANTINUCLEAR ANTIBODIES (ANA)

Background Juvenile Idiopathic Arthritis (JIA) involves a set of chronic arthritis onset in childhood. JIA can be splitted into 7 categories based on the classification International League Associations for Rheumatology (ILAR): systemic arthritis, oligoarthritis, rheumatoid factor (RF) negative polyarthritis, RF positive enthesitis related psoriatic undifferentiated arthritis. In addition to this classification, some authors propose differentiating between patients who have (+) and (-) ANA serum because there could differences these two subgroups, raising possibility homogenizing subtypes 1 . Objectives To describe variability extra-articular manifestations, treatment prevalence different serum. Methods Cross-sectional descriptive study 68 with according ILAR criteria visited transitional consultation Spanish tertiary-level hospital. Clinical features, analytical data were collected, divided ANA+ or ANA- A >1/80 title determined by IFI at least 2 occasions was considered positive. Subsequently, qualitative analyzed using Chi-Square test, means compared ANOVA analysis. Results included study. 33 grouped 35 ANA+. The group composed 28 women (80%) made up 18 (54.44%) (p= n.s.). mean age diagnosis 11 years old 9 group. Variable (n ) - P-value N=33 N=35 n(%) Subtype Oligoarthritis (20) 3 (9.09%) 17 (48.57%) <0.001 RF(-) polyarthritis (14) 8 (24.24%) 6 (17.14%) 0.6719 RF(+) (4) 0 (0%) 4 (11.43%) 0.1372 Enthesitis (33.33%) (8.57%) 0.0216 Systemic (6) (18.18%) 0.0268 Psoriatic (6.06%) (5.71%) 0.9999 Undifferentiated features Psoriasis (8) 0.2979 Uveitis (10) (20%) 0.354 (9) 0.5344 Oral genital thrush (21.21%) Raynaud Analytical HLAB27+ 12 (42.86%) (27.59%) 0.3523 RF+ (7) (3.57%) 0.1673 CCP- antibodies+ 0.1811 Treatment sDMARD (31) (36.36%) 19 (55.88%) 0.1748 bDMARD (30) 13 (39.39%) 0.6049 Corticosteroids 5 (15.15%) (2.86%) 0.1742 Oligoarticular more frequent than (9.09%), being difference statistically significant. (8.57%), as it (18.18% 0% ANA+), both Uveitis, psoriasis use corticosteroid patients, but without reaching statistical significance. Conclusion our study, literature, oligoarticular type occurred frequently group, while Although patterns uveitis appear differ groups we did not find significant difference. This due small number included, that corrected if sample expanded. Reference [1] Ravelli A, Varnier GC, Oliveira S, Castell E, Arguedas O, Magnani et al. Rheum. 2011;63(1):267–75. Acknowledgements: NIL. Disclosure Interests None Declared.